Outcome |
Relative effect 95%CI |
LoD |
Trt. better when |
|
I2 |
k (RCT/OBS)
|
Bayesian probability
|
Overall ROB
|
Publication bias |
Degree of certainty |
Endpoint importance |
Published MA |
efficacy endpoints 00 |
deaths (OS) | 0.90 [0.83, 0.98] | | < 1 | | 14% | 6 studies (6/-) | 99.2 % | some concern | serious | moderate | crucial | - |
progression or deaths (PFS) | 1.19 [0.88, 1.60] | | < 1 | | 94% | 6 studies (6/-) | 13.1 % | some concern | not evaluable | moderate | important | - |
DCR | 0.49 [0.30, 0.81] | | > 1 | | 64% | 2 studies (2/-) | 0.3 % | some concern | not evaluable | moderate | non important | - |
objective responses (ORR) | 0.86 [0.48, 1.53] | | > 1 | | 91% | 6 studies (6/-) | 30.4 % | some concern | not evaluable | moderate | non important | - |
safety endpoints 00 |
AE (any grade) | 0.74 [0.33, 1.67] | | < 1 | | 51% | 3 studies (3/-) | 76.5 % | some concern | not evaluable | moderate | non important | - |
AE (grade 3-4) | 0.47 [0.10, 2.17] | | < 1 | | 98% | 3 studies (3/-) | 83.4 % | some concern | not evaluable | moderate | non important | - |
AE leading to death (grade 5) | 1.24 [0.67, 2.31] | | < 1 | | 0% | 3 studies (3/-) | 24.5 % | some concern | not evaluable | moderate | non important | - |
AE leading to treatment discontinuation (any grade) | 0.53 [0.16, 1.78] | | < 1 | | 94% | 3 studies (3/-) | 84.7 % | some concern | not evaluable | moderate | non important | - |
SAE (any grade) | 1.26 [0.86, 1.83] | | < 1 | | 0% | 1 study (1/-) | 11.9 % | NA | not evaluable | | non important | - |
STRAE (any grade) | 1.31 [0.54, 3.21] | | < 1 | | 85% | 2 studies (2/-) | 27.5 % | some concern | not evaluable | moderate | non important | - |
STRAE (grade 3-4) | 1.80 [1.33, 2.44] | | < 1 | | 0% | 1 study (1/-) | 0.0 % | NA | not evaluable | | non important | - |
TRAE (any grade) | 0.47 [0.19, 1.16] | | < 1 | | 96% | 6 studies (6/-) | 95.0 % | some concern | not evaluable | moderate | non important | - |
TRAE (grade 3-4) | 0.45 [0.14, 1.46] | | < 1 | | 97% | 4 studies (4/-) | 90.8 % | some concern | not evaluable | moderate | non important | - |
TRAE leading to death (grade 5) | 1.92 [0.46, 8.11] | | < 1 | | 0% | 4 studies (4/-) | 18.7 % | some concern | not evaluable | moderate | non important | - |
TRAE leading to discontinuation (any grade) | 0.70 [0.24, 2.06] | | < 1 | | 94% | 4 studies (4/-) | 73.9 % | some concern | not evaluable | moderate | non important | - |
TRAE leading to discontinuation (grade 3-4) | 2.12 [1.55, 2.90] | | < 1 | | 0% | 1 study (1/-) | 0.0 % | NA | not evaluable | | non important | - |
TRAE (grade 3-4) endpoints 00 |
Alopecia TRAE (grade 3-4) | 0.50 [0.08, 3.03] | | < 1 | | 0% | 4 studies (4/-) | 77.5 % | some concern | not evaluable | moderate | non important | - |
Anaemia TRAE (grade 3-4) | 0.46 [0.15, 1.40] | | < 1 | | 89% | 5 studies (5/-) | 91.4 % | some concern | not evaluable | moderate | non important | - |
Asthenia TRAE (grade 3-4) | 0.48 [0.20, 1.14] | | < 1 | | 40% | 4 studies (4/-) | 95.1 % | some concern | not evaluable | moderate | non important | - |
Blood creatinine increased TRAE (grade 3-4) | 0.73 [0.09, 6.29] | | < 1 | | 0% | 2 studies (2/-) | 61.1 % | some concern | not evaluable | moderate | non important | - |
Colitis TRAE (grade 3-4) | 0.16 [0.01, 3.11] | | < 1 | | 0% | 1 study (1/-) | 88.6 % | NA | not evaluable | | non important | - |
Constipation TRAE (grade 3-4) | 0.97 [0.06, 15.52] | | < 1 | | 0% | 2 studies (2/-) | 50.9 % | some concern | not evaluable | moderate | non important | - |
Decreased appetite TRAE (grade 3-4) | 0.54 [0.23, 1.29] | | < 1 | | 56% | 5 studies (5/-) | 91.8 % | some concern | not evaluable | moderate | non important | - |
Diabetes TRAE (grade 3-4) | 0.94 [0.02, 47.47] | | < 1 | | 0% | 1 study (1/-) | 51.2 % | NA | not evaluable | | non important | - |
Diarrhoea TRAE (grade 3-4) | 0.61 [0.26, 1.46] | | < 1 | | 65% | 5 studies (5/-) | 86.4 % | some concern | not evaluable | moderate | non important | - |
Dizziness TRAE (grade 3-4) | 0.73 [0.09, 6.31] | | < 1 | | 0% | 2 studies (2/-) | 61.0 % | low | not evaluable | high | non important | - |
Dry skin TRAE (grade 3-4) | 0.97 [0.06, 15.52] | | < 1 | | 0% | 2 studies (2/-) | 50.9 % | some concern | not evaluable | moderate | non important | - |
Dysgeusia TRAE (grade 3-4) | 0.97 [0.06, 15.52] | | < 1 | | 0% | 2 studies (2/-) | 50.9 % | some concern | not evaluable | moderate | non important | - |
Endocrine disorders TRAE (grade 3-4) | 9.86 [0.54, 180.88] | | < 1 | | 0% | 1 study (1/-) | 6.4 % | NA | not evaluable | | non important | - |
Fatigue TRAE (grade 3-4) | 0.73 [0.31, 1.73] | | < 1 | | 70% | 5 studies (5/-) | 76.0 % | some concern | serious | moderate | non important | - |
Febrile neutropenia TRAE (grade 3-4) | 0.08 [0.00, 1.40] | | < 1 | | 0% | 1 study (1/-) | 95.7 % | NA | not evaluable | | non important | - |
Gastrointestinal disorders TRAE (grade 3-4) | 1.73 [1.04, 2.86] | | < 1 | | 0% | 1 study (1/-) | 1.7 % | NA | not evaluable | | non important | - |
Hepatitis TRAE (grade 3-4) | 7.60 [0.40, 144.43] | | < 1 | | 0% | 1 study (1/-) | 9.1 % | NA | not evaluable | | non important | - |
Hepatobiliary disorders TRAE (grade 3-4) | 1.81 [0.97, 3.36] | | < 1 | | 0% | 1 study (1/-) | 3.0 % | NA | not evaluable | | non important | - |
Hyperthyroidism TRAE (grade 3-4) | 0.94 [0.02, 47.47] | | < 1 | | 0% | 1 study (1/-) | 51.2 % | NA | not evaluable | | non important | - |
Hypophysitis TRAE (grade 3-4) | 3.77 [0.17, 84.06] | | < 1 | | 0% | 1 study (1/-) | 20.4 % | NA | not evaluable | | non important | - |
Hypothyroidism TRAE (grade 3-4) | 1.59 [0.20, 12.36] | | < 1 | | 0% | 3 studies (3/-) | 32.9 % | some concern | not evaluable | moderate | non important | - |
Increase AST TRAE (grade 3-4) | 1.95 [0.82, 4.61] | | < 1 | | 0% | 2 studies (2/-) | 6.5 % | some concern | not evaluable | moderate | non important | - |
Increased ALT TRAE (grade 3-4) | 0.97 [0.38, 2.48] | | < 1 | | 0% | 2 studies (2/-) | 52.2 % | some concern | not evaluable | moderate | non important | - |
Increased lipase level TRAE (grade 3-4) | 1.74 [0.36, 8.39] | | < 1 | | 50% | 2 studies (2/-) | 24.5 % | some concern | not evaluable | moderate | non important | - |
Infusion-related reactions TRAE (grade 3-4) | 0.95 [0.09, 10.52] | | < 1 | | 0% | 2 studies (2/-) | 51.6 % | some concern | not evaluable | moderate | non important | - |
Leucopenia TRAE (grade 3-4) | 2.43 [0.23, 25.98] | | < 1 | | 34% | 2 studies (2/-) | 23.2 % | low | not evaluable | high | non important | - |
Mucosal inflammation TRAE (grade 3-4) | 0.20 [0.01, 4.07] | | < 1 | | 77% | 2 studies (2/-) | 85.1 % | low | not evaluable | high | non important | - |
Nausea TRAE (grade 3-4) | 0.59 [0.25, 1.39] | | < 1 | | 56% | 5 studies (5/-) | 88.7 % | some concern | not evaluable | moderate | non important | - |
Neutropenia TRAE (grade 3-4) | 0.25 [0.08, 0.74] | | < 1 | | 88% | 5 studies (5/-) | 99.4 % | some concern | serious | moderate | non important | - |
Palmar-plantar erythrodysaesthesia syndrome TRAE (grade 3-4) | 1.04 [0.32, 3.44] | | < 1 | | 60% | 3 studies (3/-) | 47.2 % | some concern | not evaluable | moderate | non important | - |
Pancreatitis TRAE (grade 3-4) | 0.47 [0.02, 14.02] | | < 1 | | 0% | 1 study (1/-) | 66.7 % | NA | not evaluable | | non important | - |
Peripheral neuropathy TRAE (grade 3-4) | 1.13 [0.44, 2.87] | | < 1 | | 25% | 4 studies (4/-) | 39.9 % | some concern | not evaluable | moderate | non important | - |
Peripheral sensory neuropathy TRAE (grade 3-4) | 1.33 [0.50, 3.53] | | < 1 | | 10% | 2 studies (2/-) | 28.5 % | some concern | not evaluable | moderate | non important | - |
Pneumonitis TRAE (grade 3-4) | 3.77 [0.17, 84.06] | | < 1 | | 0% | 1 study (1/-) | 20.4 % | NA | not evaluable | | non important | - |
Pruritus TRAE (grade 3-4) | 0.97 [0.06, 15.52] | | < 1 | | 0% | 2 studies (2/-) | 50.9 % | some concern | not evaluable | moderate | non important | - |
Rash TRAE (grade 3-4) | 1.44 [0.11, 18.83] | | < 1 | | 0% | 2 studies (2/-) | 39.1 % | low | not evaluable | high | non important | - |
Renal and urinary disorders TRAE (grade 3-4) | 5.92 [0.71, 49.31] | | < 1 | | 0% | 1 study (1/-) | 5.1 % | NA | not evaluable | | non important | - |
Respiratory, thoracic and mediastinal disorders TRAE (grade 3-4) | 13.96 [1.83, 106.45] | | < 1 | | 0% | 1 study (1/-) | 0.6 % | NA | not evaluable | | non important | - |
Severe skin reaction TRAE (grade 3-4) | 1.88 [0.06, 56.28] | | < 1 | | 0% | 1 study (1/-) | 36.0 % | NA | not evaluable | | non important | - |
Skin and subcutaneous tissue disorders TRAE (grade 3-4) | 4.36 [1.79, 10.66] | | < 1 | | 0% | 1 study (1/-) | 0.1 % | NA | not evaluable | | non important | - |
Stomatitis TRAE (grade 3-4) | 0.34 [0.02, 6.97] | | < 1 | | 77% | 2 studies (2/-) | 75.7 % | low | not evaluable | high | non important | - |
Thrombocytopenia TRAE (grade 3-4) | 1.00 [0.38, 2.62] | | < 1 | | 46% | 3 studies (3/-) | 50.3 % | some concern | not evaluable | moderate | non important | - |
Vomiting TRAE (grade 3-4) | 0.56 [0.26, 1.24] | | < 1 | | 41% | 4 studies (4/-) | 92.3 % | some concern | not evaluable | moderate | non important | - |
Weight decreased TRAE (grade 3-4) | 0.44 [0.06, 3.49] | | < 1 | | 36% | 3 studies (3/-) | 77.9 % | some concern | not evaluable | moderate | non important | - |