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mNSCLC - L2 - EGFR mutant, ... , meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths (OS) 0.84 [0.64, 1.11]< 10%3 studies (3/-)88.7 %some concernnot evaluable moderatecrucial-
progression or deaths (PFS) 0.29 [0.21, 0.42]< 122%3 studies (3/-)100.0 %some concernnot evaluable moderateimportant-
DCR 3.85 [2.18, 6.82]> 10%1 study (1/-)100.0 %NAnot evaluable non important-
objective responses (ORR) 6.71 [2.57, 17.49]> 168%3 studies (3/-)100.0 %some concernnot evaluable moderatenon important-

safety endpoints 00

AE (any grade) 0.40 [0.06, 2.59]< 10%2 studies (2/-)83.2 %some concernnot evaluable moderatenon important-
AE (grade 3-4) 0.25 [0.10, 0.65]< 124%2 studies (2/-)99.8 %some concernnot evaluable moderatenon important-
AE leading to death (grade 5) 1.83 [0.27, 12.54]< 10%2 studies (2/-)27.1 %some concernnot evaluable moderatenon important-
TRAE (any grade) 0.57 [0.32, 1.03]< 10%2 studies (2/-)96.9 %some concernnot evaluable moderatenon important-
TRAE (grade 3-4) 0.12 [0.07, 0.22]< 10%2 studies (2/-)100.0 %some concernnot evaluable moderatenon important-
TRAE leading to death (grade 5) 0.99 [0.02, 50.39]< 10%1 study (1/-)50.3 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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