pdf   xlsx method abbreviations

lung cancer : non small cell (NSCLC), ... , meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths (OS) 0.97 [0.87, 1.07]< 162%11 studies (11/-)72.4 %some concernlow moderatecrucial-
progression or deaths (PFS) 0.95 [0.79, 1.15]< 191%11 studies (11/-)70.4 %some concernlow moderateimportant-
DCR 0.78 [0.52, 1.19]> 172%2 studies (2/-)12.4 %some concernnot evaluable moderatenon important-
events or deaths (EFS) 0.90 [0.74, 1.10]< 10%1 study (1/-)85.0 %NAnot evaluable non important-
objective responses (ORR) 0.97 [0.68, 1.37]> 169%9 studies (9/-)43.1 %some concernnot evaluable moderatenon important-

safety endpoints 00

AE (any grade) 0.20 [0.04, 0.91]< 10%1 study (1/-)98.1 %NAnot evaluable non important-
AE (grade 3-4) 1.02 [0.77, 1.36]< 10%1 study (1/-)43.4 %NAnot evaluable non important-
SAE (any grade) 1.00 [0.75, 1.32]< 10%1 study (1/-)50.9 %NAnot evaluable non important-
STRAE (any grade) 0.43 [0.26, 0.73]< 10%1 study (1/-)99.9 %NAnot evaluable non important-
TRAE (any grade) 0.41 [0.23, 0.75]< 166%2 studies (2/-)99.8 %some concernnot evaluable moderatenon important-
TRAE (grade 3-4) 0.58 [0.46, 0.73]< 10%2 studies (2/-)100.0 %lownot evaluable highnon important-
TRAE leading to death (grade 5) 0.69 [0.27, 1.75]< 10%3 studies (3/-)78.1 %some concernnot evaluable moderatenon important-
TRAE leading to discontinuation (any grade) 0.62 [0.24, 1.57]< 143%2 studies (2/-)84.4 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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