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endometrial cancer, immune chekpoint inhibitors , meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths (OS) 0.68 [0.60, 0.77]< 16%5 studies (5/-)100.0 %some concernnot evaluable moderatecrucial2
PFS (extension) 0.56 [0.48, 0.66]< 10%1 study (1/-)100.0 %NAnot evaluable important-
progression or deaths (PFS) 0.58 [0.51, 0.67]< 150%8 studies (8/-)100.0 %lownot evaluable highimportant2
objective responses (ORR) 2.97 [2.12, 4.18]> 10%1 study (1/-)100.0 %NAnot evaluable non important-

safety endpoints 00

AE (any grade) 0.99 [0.54, 1.82]< 10%5 studies (5/-)51.5 %lownot evaluable highnon important-
AE (grade 3-4) 0.61 [0.29, 1.28]< 10%1 study (1/-)90.5 %NAnot evaluable non important-
AE (grade 3-5) 1.87 [1.40, 2.50]< 163%5 studies (5/-)0.0 %lownot evaluable highnon important-
AE leading to death (grade 5) 2.12 [0.46, 9.79]< 138%4 studies (4/-)16.8 %lownot evaluable highnon important-
AE leading to treatment discontinuation (any grade) 2.79 [0.97, 8.04]< 194%3 studies (3/-)2.9 %lownot evaluable highnon important-
SAE (any grade) 2.19 [1.20, 4.00]< 184%2 studies (2/-)0.5 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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