Study Exclusion reasons Remarks Reference(s)
PRISM, 2019 randomized controlled trial inadequate or absent control group phase II trial to evaluate whether administering IPI once every 12 weeks (modified), instead of once every 3 weeks (standard), in combination with NIVO, is associated with a favorable toxicity profile.

Buckley BMC Cancer 2019; 19:1102 10.1186/s12885-019-6273-1

Naveen S. Vasudev JCO 42, 312-323(2024) 10.1200/JCO.23.00236

 
COSMIC-313, 2023 randomized controlled trial not relevant exposure

Choueiri TK N Engl J Med 2023;388:1767-1778 May 2023 10.1056/NEJMoa2212851

Choueiri TK N Engl J Med 2023; 388:1767-1778-. 10.1056/NEJMoa2212851