table network network 2
demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only
COVID 19 all comersCOVID-19 mild to moderateCOVID-19 severe or critically
COVID 19 hospitalizedCOVID 19 all comersCOVID-19 mild to moderateCOVID-19 severe or critically
antiviral and associated therapy
azithromycin Sekhavati RECOVERY ... COALITION I Covid-19 Brazil ... Rashad A ... COALITION II Covid-19 Brazil ...
azvudine Ren
baloxavir marboxil Lou Y
bromhexine Li T
chloroquine and derivatives
chloroquine Huang
hydroxychloroquine HAHPS ORCHID RECOVERY SOLIDARITY ... Chen NO COVID-19 ... Abd-Elsalam TEACH HYCOVID Gonzalez ... NOR-Solidarity ... Coalition Covid-19 Brazil I ... FACCT Trial HYDRA ...
Emtricitabine/tenofovir plus colchicine plus rosuvastatin Gaitan-Duarte ...
Ensitrelvir (XOCOVA) Mukae - Phase 2a
favipiravir Udwadia AVIFAVIR Lou ... Chang Chen et al. NCT04310228-FAVI ... Dabbous HM FACCT Trial Udwadia AVIFAVIR NCT04542694 Ruzhentsova T Solaymani-Dodaran Shinkai
favipiravir plus interferon Khamis
hydroxychloroquine plus macrolides
azithromycin plus hydroxychloroquine ProPAC-COVID Coalition Covid-19 Brazil I ...
ivermectin Gonzalez ... Shahbaznejad Chaccour Kirti Krolewiecki I-TECH ... Galan Galan
ivermectin plus doxycycline Hashim A NCT04523831 ...
lopinavir/ritonavir RECOVERY SOLIDARITY ... Nojomi Ader ... ELACOI ... Cao REMAP-CAP ...
Lopinavir/ritonavir plus hydroxychloroquine REMAP-CAP ...
lopinavir/ritonavir plus interferon ß-1a Ader ...
lopinavir/ritonavir, ribavirin and interferon beta-1b Hung et al.
niclosamide Abdulamir
remdesivir NIH NIAID ACTT-1 DisCoVeRy ... SOLIDARITY ... Mahajan Norwegian NOR study ... Andreas ... GS-US-540-5774, 10 days GS-US-540-5774, 5 days GS-US-540-5773 ... CAP-China ...
sofosbuvir Alavi-moghaddam
sofosbuvir and daclatasvir Sadeghi Yakoot Mobarak S ...
sofosbuvir and ledipasvir Elgohary Nourian A
tenofovir/emtricitabine Gaitan-Duarte ...
umifenovir (arbidol) Nojomi ELACOI ... ELACOI ...

85 studies excluded by filtering options 0

4823 Jun C, 2020 113high risk of bias
4861 Cai -FAVIPIRAVIR, 2020 1310not a RCTrisk of bias not avaialble
4899 ChiCTR2000029826 (Cancelled by the investigator), 0 210excludedrisk of bias not avaialble
4905 ChiCTR2000029975, 0 2300excludednot a RCTrisk of bias not avaialble
4980 jRCTs041190120, 2020 113high risk of bias
4987 CloroCOVID19, 2020 213excludedhigh risk of bias
5209 SIMPLE (Grein), 0 2300excludednot a RCTrisk of bias not avaialble
5210 Ye et al., 2020 2990excludednot a RCTrisk of bias not avaialble
5226 Duke university (Hydroxychloroquine), 2020 210excludedrisk of bias not avaialble
5259 Duke University azithromycin, 2020 210excludedrisk of bias not avaialble
5288 Barbosa, 2020 2130excludednot a RCTrisk of bias not avaialble
5290 UAIIC, 2021 010selection pending
5314 Magagnoli (HC AZ), 2020 1133not a RCThigh risk of bias
5351 Mallat, 2020 2130excludednot a RCTrisk of bias not avaialble
5365 Rosenberg, 2020 1133not a RCThigh risk of bias
5365 Rosenberg, 2020 1133not a RCThigh risk of bias
5365 Rosenberg, 2020 1133not a RCThigh risk of bias
5371 Carlucci, 2020 0134selection pending
5375 Mehra, 2020 2133excludednot a RCThigh risk of bias
5375 Mehra, 2020 2133excludednot a RCThigh risk of bias
5482 Sbidian (HCQ plus AZI), 2020 1134not a RCThigh risk of bias
5490 Kurd, 2020 0100selection pending
5509 Lagier, 2020 1134not a RCThigh risk of bias
5513 Arshad (HCQ AZ), 2020 1134not a RCThigh risk of bias
5536 Ansarin, 2020 113high risk of bias
5546 remdesevir external control, 0 0130selection pending
5559 Davido, 2020 1134not a RCThigh risk of bias
5599 Karolyi, 2020 0130selection pending
5987 Duke university HCQ-AZI, 2020 110risk of bias not avaialble
5989 Yethindra, 2020 113high risk of bias
6034 Huang, 2020 0990selection pending
6064 Glorial F, 2020 1100not a RCTrisk of bias not avaialble
6082 ICON, 2020 0130selection pending
6083 IFORS (Pott-Junior), 2020 213excludedhigh risk of bias
6095 Camprubi, 2020 1110not a RCTrisk of bias not avaialble
6096 Elgazzar - treatment, 2020 213excludedhigh risk of bias
6184 Erdem, 2020 2110excludednot a RCTrisk of bias not avaialble
6244 Holubar M, 2021 110risk of bias not avaialble
6246 IRCT20150808023559N20, 0 010selection pending
6248 IRCT20151227025726N14 // U07, 0 010selection pending
6252 NCT04376814-Group A, 2020 0310selection pending
6255 IRCT20200428047228N1 // U07, 0 010selection pending
6262 Yamamura, 2020 2300excludednot a RCTrisk of bias not avaialble
6263 Calik, 2020 1104not a RCThigh risk of bias
6265 Shenoy S, 2021 113high risk of bias
6267 Murohashi, 2020 2100excludednot a RCTrisk of bias not avaialble
6287 Kocayigit H, 2020 1100not a RCTrisk of bias not avaialble
6332 Rodriguez-Molinero, 2020 1100not a RCTrisk of bias not avaialble
6368 Niaee (vs placebo), 2020 213excludedhigh risk of bias
6369 Ahmed, 2020 113high risk of bias
6370 Chachar, 2020 113high risk of bias
6375 Cadegiani -Iver, 2020 2990excludednot a RCTrisk of bias not avaialble
6381 Espitia-Hernandez, 2020 1310not a RCTrisk of bias not avaialble
6381 Espitia-Hernandez, 2020 1310not a RCTrisk of bias not avaialble
6382 Khan, 2020 0130selection pending
6382 Khan, 2020 0130selection pending
6383 Soto-Becerra, 2020 0122selection pending
6383 Soto-Becerra, 2020 0122selection pending
6384 Spoorthi, 2020 1310not a RCTrisk of bias not avaialble
6384 Spoorthi, 2020 1310not a RCTrisk of bias not avaialble
6384 Spoorthi, 2020 1310not a RCTrisk of bias not avaialble
6384 Spoorthi, 2020 1310not a RCTrisk of bias not avaialble
6411 Rocco, 2020 113high risk of bias
6449 Okumuş, 2020 113high risk of bias
6516 Eslami, 2020 1310not a RCTrisk of bias not avaialble
6526 Dabbous, 2021 213excludedhigh risk of bias
6575 Bukhari, 2021 113high risk of bias
6624 Babalola, 2021 113high risk of bias
6625 Nasir, 2020 2310excludednot a RCTrisk of bias not avaialble
6626 RIVET-COV (Mohan) (12mg and 24mg), 2021 113high risk of bias
6643 Patel, 2021 103high risk of bias
6675 Silva, 2021 113high risk of bias
6703 Sali, 2021 113high risk of bias
6749 Chen_oseltamivir, 2020 1134not a RCThigh risk of bias
6750 Chen_arbidol, 2020 1134not a RCThigh risk of bias
6751 Chen_lopi_rito, 2020 1134not a RCThigh risk of bias
6767 Tolouian, 2021 103high risk of bias
7313 Abd-Elsalam, 2021 113high risk of bias
7319 Fontanesi, 2021 110risk of bias not avaialble
7995 Hazan, 2021 2320excludednot a RCTrisk of bias not avaialble
8362 Winthrop, 2021 010selection pending
9127 Mobarak (DISCOVER), 2021 110risk of bias not avaialble
9263 EPIC-SR, 0 110risk of bias not avaialble
9462 Mayer, 2022 000selection pending
9976 ANTICOV, 0 000selection pending

 

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