antiviral and associated therapy living meta-analysis of clinical studies

demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only

	COVID-19 severe or critically

	COVID-19 prophylaxis (excluding children)
antiviral and associated therapy
chloroquine and derivatives
hydroxychloroquine	Barnabas RV COVID PREP ... COVID PREP HCQ ... HERO-HCQ ... PATCH-cohort 3 PreP ... COVID-PEP-Post exposure ... BCN PEP-CoV-2-Study 1 ... EPICOS ... Rojas-Serrano

5448	COVID-19 Global Rheumatology Alliance, 2020	0	13	0	selection pending
5521	Del Amo, 2020	2	0	0	excluded		risk of bias not avaialble
6079	NCT04422561 (Shouman), 2020	1	1	3			high risk of bias
6097	Elgazzar - prophylaxis, 2020	2	1	3	excluded		high risk of bias
6372	Alam, 2020	0	31	3	selection pending
6373	Behera, 2020	1	20	0		not a RCT	risk of bias not avaialble
6374	NCT04425850 (Caravallo), 2020	2	31	0	excluded	not a RCT	risk of bias not avaialble
6491	Ivercar-Tuc, 2021	1	1	3			high risk of bias
6677	Mikhaylov, 2021	1	1	0			risk of bias not avaialble
8328	Behera, 2021	0	13	0	selection pending
9262	EPIC PEP, 2022	1	1	0			risk of bias not avaialble
10322	Elgazzar, 0	2	0	0	excluded		risk of bias not avaialble
10323	Seet 2021, 2021	1	1	3			high risk of bias