• immune chekpoint inhibitors
• anti-PD-(L)1
• atezolizumab based treatment
• atezolizumab plus bevacizumab
• atezolizumab plus cabozantinib
• camrelizumab based treatment
• durvalumab based treatment
• durvalumab plus bevacizumab
• nivolumab based treatment
• nivolumab alone
• pembrolizumab based treatment
• pembrolizumab alone
• pembrolizumab plus lenvatinib
• sintilimab based treatment
• sintilimab
• Tislelizumab
• Immune checkpoint association
• durvalumab plus tremelimumab
• nivolumab plus ipilimumab
• nivolumab plus ipilimumab plus SoC
• VEGF(R) inhibitor
• bevacizumab based treatment
• bevacizumab

• versus all
• vs chemotherapy
• vs Standard of Care (SoC)
• vs immune chekpoint inhibitors
• vs anti-PD-(L)1
• vs atezolizumab based treatment
• vs atezolizumab plus bevacizumab
• vs nivolumab based treatment
• vs nivolumab alone
• vs non active control
• vs no additional treatment
• vs placebo
• vs VEGF(R) inhibitor
• vs lenvatinib
• vs sorafenib

  Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

color = results color = ROB demonstrated suggested inconclusive safety concern ongoing study not assessable low moderate serious ongoing study display ongoing demontrated benefit only