• immune chekpoint inhibitors
• anti-PD-(L)1
• cemiplimab
• durvalumab based treatment
• durvalumab alone
• sintilimab based treatment
• sintillimab plus SoC
• Immune checkpoint association
• durvalumab plus tremelimumab
• nivolumab plus ipilimumab
• nivolumab plus ipilimumab plus SoC

• versus all
• vs chemotherapy
• vs platinum-based chemotherapy
• vs Standard of Care (SoC)
• vs placebo plus SoC
• vs non active control
• vs placebo
• vs placebo plus BSC

  Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

color = results color = ROB demonstrated suggested inconclusive safety concern ongoing study not assessable low moderate serious ongoing study display ongoing demontrated benefit only