• immune chekpoint inhibitors
• anti-CTLA-4
• tremelimumab
• anti-PD-(L)1
• atezolizumab based treatment
• atezolizumab plus cometinib
• atezolizumab plus SoC
• nivolumab based treatment
• nivolumab alone
• nivolumab followed by ipilimumab
• Immune checkpoint association
• nivolumab plus ipilimumab
• relatlimab plus nivolumab

• versus all
• vs chemotherapy
• vs non platinum-based chemotherapy
• vs alkylating agents
• vs dacarbazine
• vs Standard of Care (SoC)
• vs placebo plus SoC
• vs immune chekpoint inhibitors
• vs anti-CTLA-4
• vs ipilimumab based treatment
• vs ipilimumab alone
• vs ipilimumab followed by nivolumab
• vs anti-PD-(L)1
• vs nivolumab based treatment
• vs nivolumab alone
• vs pembrolizumab based treatment
• vs pembrolizumab alone
• vs Immune checkpoint association
• vs nivolumab plus ipilimumab

  Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

color = results color = ROB demonstrated suggested inconclusive safety concern ongoing study not assessable low moderate serious ongoing study display ongoing demontrated benefit only