• immune chekpoint inhibitors
• anti-CTLA-4
• ipilimumab based treatment
• ipilimumab plus SoC
• anti-PD-(L)1
• atezolizumab based treatment
• atezolizumab plus SoC
• durvalumab based treatment
• durvalumab plus etoposide and platin
• nivolumab based treatment
• nivolumab alone
• pembrolizumab based treatment
• pembrolizumab plus SoC
• Immune checkpoint association
• durvalumab plus tremelimumab
• durvalumab plus tremelimumab plus SoC
• nivolumab plus ipilimumab

• versus all
• vs chemotherapy
• vs platinum-based chemotherapy
• vs platinum derivate
• vs platinum association
• vs etoposide plus platin
• vs Standard of Care (SoC)
• vs placebo plus SoC
• vs HER inhibitor
• vs HER2 inhibitor
• vs pertuzumab based treatment
• vs non active control
• vs placebo

  Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

color = results color = ROB demonstrated suggested inconclusive safety concern ongoing study not assessable low moderate serious ongoing study display ongoing demontrated benefit only