• immune chekpoint inhibitors
• anti-PD-(L)1
• atezolizumab based treatment
• atezolizumab plus bevacizumab
• nivolumab based treatment
• nivolumab alone
• pembrolizumab based treatment
• pembrolizumab plus lenvatinib
• sintilimab based treatment
• sintilimab

• versus all
• vs non active control
• vs no additional treatment
• vs VEGF(R) inhibitor
• vs lenvatinib
• vs sorafenib

  Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

color = results color = ROB demonstrated suggested inconclusive safety concern ongoing study not assessable low moderate serious ongoing study display ongoing demontrated benefit only