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meta|Evidence - COVID-19

Living meta-analysis and evidence synthesis of therapies for COVID19  

Member of the meta|Evidence galaxy

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Treament Trials
Statistically conclusive or suggested result Inconclusive results Uncertain results Safety results
0- - - -
0- - - -
3

statistically conclusive 38 % increase in clinical improvement

suggested 57 % increase in clinical improvement (14-day)

suggested 81 % increase in clinical improvement (28-day)

suggested 47 % decrease in serious adverse events

inconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical improvement (7-day); clinical improvement (time to event analysis only); mechanical ventilation; recovery; adverse events--
1 / 2 noneinconclusive results for: death D28; death or transfer to ICU; deaths; mechanical ventilation; viral clearance by day 7; ICU admission

statistically conclusive 48 % decrease in clinical deterioration but the degree if certainty is unassessable

-
0 / 2 noneinconclusive results for: deaths; hospital discharge; ICU admission--
0- - - -
0 / 1 noneinconclusive results for: deaths--
1 none-

suggested 39 % decrease in death D28 but the degree if certainty is unassessable

suggested 39 % decrease in deaths but the degree if certainty is unassessable

suggested 34 % decrease in death or ventilation but the degree if certainty is unassessable

suggested 48 % increase in hospital discharge but the degree if certainty is unassessable

-
4

suggested 2.7-fold increase in viral clearance by day 7

inconclusive results for: death D28; deaths; clinical improvement; clinical improvement (14-day); hospitalization; viral clearance ; viral clearance (time to event analysis only); viral clearance by day 14; serious adverse events; adverse events

suggested 91 % increase in clinical improvement (7-day) but the degree if certainty is unassessable

-
0 / 1 noneinconclusive results for: deaths; deaths (time to event analysis only)--
0- - - -
1 noneinconclusive results for: deaths; death or ventilation; Major bleeding

statistically conclusive 27 % increase in clinical improvement (28-day) but the degree if certainty is unassessable

-
0- - - -

Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant

149
treatments
  718
studies with results
  1743
studies screend
  1629
references

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N), Université de Lyon (UdL/Idex), and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

     

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